Clinical warning of hemophagocytic syndrome caused by Epstein-Barr virus

Abstract Objectives This study aimed to compare the clinical features and laboratory tests of infectious mononucleosis (IM) hemophagocytic syndrome (HLH) caused by Epstein-Barr virus (EBV) in 1–3-year-old children explore risk factor HLH EBV (EBV-HLH). Methods The data 92 with infection admitted our hospital from 2011 2019 were collected; 61 cases diagnosed as EBV-IM, 31 EBV-HLH. subjects’ manifestations analyzed retrospectively. Results Compared EBV-IM patients, EBV-HLH patients had longer durations fever, both before hospitalization overall, a higher probability hepatomegaly. levels ALT, AST, LDH, TG, SF, D-Dimer plasma DNA load significantly than those patients. absolute values CD3 + , CD4 CD8 NK, CD3-CD19 cells IgA IgM lower was positively correlated PT, TT, ?-HBDH, CK, Scr, BUN, UA, CRP level Among 10 different potential markers, at cut-off point 1721.500 ?g/L, sensitivity specificity 88.90 90.20%, respectively. Conclusion may be good prognostic indicator EBV.